Spironolactone is frequently used as a component of hormone replacement therapy in transgender women , especially in the United States (where cyproterone acetate is not available), usually in addition to an estrogen .    Spironolactone significantly depresses plasma testosterone levels, reducing them to female/castrate levels at sufficient doses and in combination with estrogen. The clinical response consists of, among other effects, decreased male pattern body hair , the induction of breast development , feminization in general, and lack of spontaneous erections . 
It’s heart wrenching to hear stories like yours. To lend some insight, I have most of my patients on estrogen blockers as well. This is something that I find necessary even though we replace to the normal range only. We recommend against GHRP-6 and all growth hormone treatment, so I cant’ speak directly to that. His testosterone dose is higher than what I would start a patient at, but it’s not exorbitant. That, however, is only part of the picture. Proper dosing is dependent upon the observation of how a patient reacts to a dose over time. So, that dose could be entirely too high for him even though I would say it is on the spectrum of normal dosing in general.
Effects of steroid withdrawal are known to emulate and kick start many other medical complications as well. Weakness, loss of appetite, fatigue, nausea, weight loss, vomiting, diarrhea (further resulting in liquid and electrolyte complications), as well as abdominal pain are some of the most common effects that steroid withdrawal is often associated with. Constant decrease in blood pressure which simultaneously causes a person to faint or causes fits and dizziness are other complications the steroid use can cause.
Blood sugar levels are known to have dropped in many people who consume steroids. In women, menstrual changes have been reported widely. Muscle and joint pains, fever, changes in mentality, as well as elevation in calcium levels have been reported in some cases. Gastrointestinal contractions decrease dramatically which may ultimately lead to the swelling of the intestine .