As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes. 
Prednisone can interact with a number of different drugs, including OTC and some herbal preparations. Let your doctor know about all the medications you take. The most common interactions are with NSAIDs , anti-infectives (such as ciprofloxacin , some HIV medicines ), immune suppressants , diuretics ("water” pills), and anticoagulants (blood thinners), but there are many more. If you are worried that some of your medicines may be interacting, talk with your doctor or pharmacist. Alternatively, you can use our drug interaction checker .