In case of Pruritic Urticarial Papules of Pregnancy (PUPP), this is a medical condition that characterizes the occurrence of itchy bumps on the stomach or the development of rashes on the skin. It basically occurs during the trimester of pregnancy and causes great discomfort to the pregnant mother. This is a mild condition that normally does not harm women but may be a cause of concern if the itching remains unabated. Extremely itchy feet may cause Cholestasis, a rare condition characterized by the accumulation of the bile salt in the body. The itching is so severe at times that it forces pregnant women to even scratch and itch the affected area to such an extent that it may bleed.
Cell lysis is used in laboratories to break open cells and purify or further study their contents. Lysis in the laboratory may be affected by enzymes or detergents or other chaotropic agents . Mechanical disruption of cell membranes, as by repeated freezing and thawing, sonication , pressure, or filtration may also be referred to as lysis. Many laboratory experiments are sensitive to the choice of lysis mechanism; often it is desirable to avoid mechanical shear forces that would denature or degrade sensitive macromolecules, such as proteins and DNA , and different types of detergents can yield different results. The unprocessed solution immediately after lysis but before any further extraction steps is often referred to as a crude lysate .