It seems strange, then, that allergic reactions to corticosteroids actually occur—especially since these medications are used to treat allergic reactions. While severe allergic reactions to corticosteroids are extremely rare, they do in fact occur. Most allergic reactions to corticosteroids are less severe, however, and result from the topical formulations—occurring in up to 6% of people. Allergic reactions to oral or injected formulations are rarer, occurring in less than 1% of people. Causes of allergic reactions to corticosteroids may be due to IgE antibodies , or as a result of delayed-type hypersensitivity reactions caused by T-cells (a type of white blood cell).
Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.
12 years or older:
Cream, gel, ointment: Apply a thin film to the affected area once or twice a day.
Foam, lotion: Apply twice a day (once in the morning and once at night)
-Treatment should be limited to two weeks.
-Use should be limited to 45 g per week.
-This topical drug should not be used with occlusive dressings, unless directed by a healthcare provider.
-If an infection develops, appropriate antimicrobial therapy should be initiated.
Use: Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses