One last point: Because steroids have all these side effects, a lot of abusers will then take other drugs to offset the effect—steroid abuse causes you to grow man-boobs, so people take another drug to mitigate those side effects. Guys who take steroids often also take augmenting drugs to decrease estrogen production or to improve athletic performance even further, like human growth hormone, insulin-like growth factor 1, insulin, erythropoietin, stimulants, diuretics, levothyroxine, and/or gamma-hydroxybutyrate, according to the study in FP Essentials . That means on top of all these side effects of steroids, most abusers are also looking at a whole separate list of effects from their peripheral drug habits.
The structure of cyclocreatine is fairly flat (planar), which aids in passive diffusion across membranes. It has been used with success in an animal study, where mice suffered from a SLC6A8 (creatine transporter at the blood brain barrier) deficiency, which is not responsive to standard creatine supplementation.  This study failed to report increases in creatine stores in the brain, but noted a reduction of mental retardation associated with increased cyclocreatine and phosphorylated cyclocreatine storages.  As demonstrated by this animal study and previous ones, cyclocreatine is bioactive after oral ingestion   and may merely be a creatine mimetic, able to phosphorylate ADP via the creatine kinase system.