In patients where the nasal polyps do not seem to respond to the above protocol (or if patient is refusing surgery), the addition of a very strong drug called Zyflo (zileuton) may be of benefit. This drug can cause liver damage (in <10% of patients) and as such, liver function bloodwork (AST/ALT) is required every month for 3 months and yearly thereafter. As long as the AST/ALT numbers do not exceed 150 (yes, it is higher than what is considered normal), it is generally considered safe to continue with this drug (though would check bloodwork weekly if that happens to ensure stability). Getting an immunologist involved in the care of such patients would also be beneficial, especially for those patients where the nasal polyps are particularly resistant to standard treatment.
Improving dietary intake of the trace element selenium through foods such as Brazil nuts, crimini mushrooms , cod, shrimp, and halibut may help prevent or treat nasal polyps. The potential beneficial effects of selenium on nasal polyps are based on the role of this trace element in the antioxidant system of the body: selenium is a key component of several enzymes involved in antioxidant defense . To get the most out of selenium's health benefits, combine selenium rich foods with foods high in vitamin E (selenium boosts the effectiveness of vitamin E).
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