Antipsychotics are a class of drugs used commonly to treat psychotic disorders -- conditions in which thinking can be irrational, and people have false beliefs (delusions) or perceptions (hallucinations) -- and sometimes to treat mood disorders such as bipolar disorder or major depression. Different antipsychotics vary in their side effects, and some people have more trouble with certain side effects than with others. The doctor can change medications or dosages to help minimize unpleasant side effects. A drawback to some antipsychotic medications is their potential to cause sedation and problems with involuntary movements as well as weight gain and changes in blood sugar or cholesterol, which require periodic laboratory monitoring.
2-Imidazoline derivatives, such as oxymetazoline , may participate in negative feedback on endogenous norepinephrine production. Therefore, after cessation of prolonged use, there will be inadequate sympathetic vasoconstriction in the nasal mucosa , and domination of parasympathetic activity can result in increased secretions and nasal edema .   Evidence suggests that if oxymetazoline is used only nightly for allergic rhinitis (instead of more frequent dosage as may be directed on product label), it may be used longer than one week without high risk of rhinitis medicamentosa especially with use of intranasal steroid like fluticasone furoate. 
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