It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
It is about ethics and honesty. Like it or not, we all look up to these athletes as role models. Kids want to be like their favorite baseball player or footballer. They dress like them, copy their athletic moves, and they also copy their athletic choices. If an athlete that is on a national or global stage is found doping and there is no consequence, then the children that are being raised today will feel like they can do the same.
Honesty also comes through competition. When we watch a sporting event, we want to know that a fair outcome is going to be achieved. If some athletes are doping and others are not, then we view that as an unfair advantage. That’s why anti-doping efforts are emphasized and rule violators are punished severely for their choices. As technology continues to improve, however, doping is simply going to become more complicated. If testing measures don’t keep up, then there’s a good chance that many athletes will get away with find their competitive edge in this way.